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BY DOMINIQUE GABRIEL BAÑAGA Benitez, provincial consultant for economic affairs, said 83,000 overseas Filipino workers from the province may also be affected, “translating to potential loss in cash remittances amounting to P7 billion.” In line with the digital revolution, Gov. Eugenio Jose Lacson called on the department heads of the provincial government to “synchronize moves to show that the province is serious in migrating into technology-based delivery of basic services.” Benitez said the meeting is to align the departments with the vision to create a digital revolution. During the meeting, Benitez cited the digital revolution program “as a road to recovery.” About 976,000 workers in the informal economy were “highly affected during the enhanced community quarantine, according to former congressman Alfredo Benitez, speaking before officials of the provincial government attending the “Meeting on Negros Occidental’s Road Recovery Plan” at the Capitol Social Hall on Monday. “Through the program the province will create smart cities, smart systems, smart infrastructure,” he said. He added the province is signing a tripartite Memorandum of Agreement with private companies and with the Department of Information and Communications Technology, to ensure this connectivity infrastructure. BACOLOD City – The coronavirus disease 2019 (COVID-19) crisis is expected to cost Negros Occidental’s economy P1.57 billion in losses this year as firms shed profits while thousands of workers lose their jobs and income. “It starts with the basic infrastructure of connectivity. The program is to bring all local government units, all hospitals, schools into a network where they have interconnectivity. Once the infrastructure of connectivity has been established you will have different programs of E-government, E-Learning, telemedicine. We will use technology to deliver basic services,” Benitez said. “We’re looking at this year for the realization of the project,” Benitez added./PN read more
Source:https://ki.se/en/news/mechanism-controlling-multiple-sclerosis-risk-identified Jun 19 2018While the DNA sequence remains the same throughout a person’s life, the expression of the encoded genes may change with time and contribute to disease development in genetically predisposed individuals. Researchers at Karolinska Institutet in Sweden have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism. The study is published in Nature Communications.Multiple sclerosis is a chronic inflammatory disease of the central nervous system, affecting people at a relatively young age. Most are between 20 and 40 years old when they get the first symptoms, in the form of, for example numbness in the arms and legs, visual impairment and dizziness, but also fatigue and depression. The symptoms are caused by an inflammation in the brain and the spinal cord that breaks down the myelin sheath protecting the nerves, thus damaging the axons. Currently there is no cure for MS, but the disease activity can often be halted through medication.Related StoriesNature of social cognitive deficits in people with progressive multiple sclerosisResearchers move closer to finding the root cause of MSNovel imaging molecule reveals brain changes linked to progressive MSAlready over 40 years ago it was discovered that genetic variation in the so-called HLA region is the strongest risk factor for developing disease. HLA encodes molecules that are involved in the immune system. However, the specific genes and molecular mechanisms behind the emergence of the disease are not fully established.By using molecular analyses and combining several studies (so-called meta-analysis), including around 14,000 patients with MS and a control group of more than 170,000 healthy individuals, researchers at Karolinska Institutet found that people with the major risk variant HLA-DRB1*15:01 have an increased expression of the HLA-DRB1 gene, thus increasing the risk for the disease. The researchers further discovered a so-called epigenetic regulation of HLA expression as the mechanism mediating this effect.”We show for the first time that epigenetic mechanisms can cause the disease. In addition, we can connect this mechanism to the genetic variant with the strongest risk for developing MS,” says Maja Jagodic, researcher at the Department of Clinical Neuroscience at Karolinska Institutet and one of the authors of the article.The researchers also discovered a new HLA gene variant, rs9267649, which reduces the risk of developing MS. This protective variant decreases the HLA-DRB1 gene expression – through the same epigenetic regulation mechanism – thus reducing the risk for MS. The results open new avenues for potential alternative treatments based on specific epigenetic modulation, i.e. to prevent gene expression artificially. This gives hope for people with MS, as well as other autoimmune diseases.”Almost all autoimmune diseases are associated with HLA,” says Lara Kular, co-author and researcher at the same department. read more